Orlando Pirates and Enyimba will renew the great football rivalry between South Africa and Nigeria after a CAF Confederation Cup draw in Cairo on Monday placed both clubs in Group A.
A couple of north African teams, Entente Setif of Algeria and Al Ahly Benghazi of Libya, complete the section line-up in the African equivalent of the UEFA Europa League.
Enyimba and Setif have won the CAF Champions League twice each and Pirates once while Benghazi did well to reach the last 16 as they could not play at home for security reasons.
The winners will join record three-time Confederation Cup winners CS Sfaxien of Tunisia and two west African contenders, Salitas of Burkina Faso and ASC Jaraaf of Senegal.
Raja Casablanca of Morocco and Pyramids are in Group D with Nkana of Zambia, who have never lost at home in 64 CAF matches, and the winners between Namungo of Tanzania and Primeiro Agosto of Angola.